Diagnostic performance of edited 2HG MR spectroscopy of central glioma in the clinical environment

Magnetic Resonance Materials in Physics, Biology and Medicine - Oncometabolite D-2-hydroxyglutarate (2HG) is pooled in isocitrate dehydrogenase (IDH)-mutant glioma cells. Detecting 2HG by MR...     

Electrohydrodynamic‐Induced SERS Immunoassay for Extensive Multiplexed Biomarker Sensing

Cancer diagnosis and patient monitoring require sensitive and simultaneous measurement of multiple cancer biomarkers considering that single biomarker analysis present inadequate information on the underlying biological transformations. Thus, development of sensitive and selective assays for multiple biomarker detection might improve clinical diagnosis and expedite the treatment process. Herein, a microfluidic platform for the rapid, sensitive, and parallel detection of multiple cancer‐specific protein biomarkers from complex biological samples is presented. This approach utilizes alternating current electrohydrodynamic‐induced surface shear forces that provide exquisite control over fluid flow thereby enhancing target–sensor interactions and minimizing non‐specific binding. Further, the use of surface‐enhanced Raman scattering‐based spectral encoding with individual barcodes for different targets enables specific and simultaneous detection of captured protein biomarkers. Using this approach, the specific and sensitive detection of clinically relevant biomarkers including human epidermal growth factor receptor 2 (HER2); Mucin 1, cell surface associated (MUC1); epidermal growth factor receptor; and Mucin 16, cell surface associated (MUC16) at concentrations as low as 10 fg mL^?1 in patient serum is demonstrated. Successful target detection from patient samples further demonstrates the potential of this current approach for the clinical diagnosis, which envisages a clinical translation for a rapid and sensitive appraisal of clinical samples in cancer diagnostics.     

一种改进的文本特征选择方法的研究与设计

分析了特征选择采用互信息方法时文本分类性能较低的原因,认为与其在特征选择时倾向于选择稀有特征这一缺陷有很大关系。在此基础上,提出了一种基于分散度和平均频度的互信息特征选择方法。实验结果表明,改进后的互信息方法使文本分类性能有明显提高。     

General view on current conveyors

We propose a new current conveyor terminology and explain how these terms are coined. Copyright © 2004 John Wiley & Sons, Ltd.     

A Distributed Approach for Monitoring Multicast Service Availability

With the deployment of native multicast in commercial networks, multicast is getting closer to becoming a ubiquitous service in the Internet. The success of this deployment largely depends on the availability of good management tools and systems. One of the most important management tasks for multicast is to verify the availability of the service to its users. This task is usually referred to as reachability monitoring. Reachability monitoring requires a number of monitoring stations to work together to collect this information in a distributed manner in the interdomain scale. In this paper we present a general architecture for multicast reachability monitoring systems and focus on three critical functions: agent configuration, monitoring, and feedback collection. For each component, we provide a number of alternative approaches to implement the required functionality and discuss their advantages and disadvantages. Then, we focus on the feedback collection component. To a large extent, it determines the complexity and the overhead of a monitoring system. Using simulations, we compare a number of alternative approaches for feedback collection and make suggestions on when to use each. We believe our work provides insight into the issues and considerations in designing and developing multicast reachability monitoring systems.     

Effect of exchanging PbO with NiO on the structure and optical parameters action of some lanthanum borate oxide glasses

Journal of Materials Science: Materials in Electronics - This work is an attempt to estimate the effect of the exchanging of PbO with NiO on the optical and structural parameters for some...     

Cyberbullying,cyber aggression and their impact on the victim – The teacher

This paper focuses on the results of the national research of cyberbullying of Czech teachers, which was realized in year 2016 in the entire Czech Republic. The research focused on impact of cyberbullying on teachers – especially in emotional, physiological and behavioural area. The research involved a total of 5136 primary and secondary school teachers from all regions of the Czech Republic. The research has shown that a fifth of respondents (21.73%) has experienced a cyber-attack on their person, however cyberbullying during the last 12 months lasting over 1 week was confirmed only by 3.52% of the total number of respondents.